Year | Award | Category | Nominated work | Result |
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| Daytime Emmy Award | Outstanding Ingenue in a Drama Series | As the World Turns | Won |
| Soap Opera Digest Awards | Best Supporting Actress - Daytime | As the World Turns | Nominated |
| Academy of Science Fiction, Fantasy & Horror Films | Best Supporting Actress | The Hand That Rocks the Cradle | Nominated |
Venice Film Festival | Special Volpi Cup | Short Cuts | Won |
| Boston Society of Film Critics Awards | Best Actress | Vanya on 42nd Street | Won |
Golden Globe | Best Ensemble | Short Cuts | Won |
Independent Spirit Awards | Best Supporting Entertainer | Short Cuts | Nominated |
| Chlotrudis Awards | Best Actress | Vanya adaptation 42nd Street | Nominated |
| Chlotrudis Awards | Best Actress | Safe | Nominated |
Independent Spirit Awards | Best Lead Actress | Safe | Nominated |
| Los Angeles Film Critics Association Awards | Best Supporting Actress | Boogie Nights | Won |
| Academy Award | Best Supporting Actress | Boogie Nights | Nominated |
Blockbuster Entertainment Awards | Favorite Actress - Sci-Fi | The Lost World: Jurassic Park | Nominated |
Chicago Film Critics Confederation Awards | Best Supporting Actress | Boogie Nights | Nominated |
Chlotrudis Awards | Best Supportive Actress | Boogie Nights and The Myth of Fingerprints | Nominated |
Florida Film Critics Circle Awards | Best Ensemble | Boogie Nights | Won |
Best Supporting Actress | Boogie Nights | Won |
Golden Globes | Best Performance by an Actress in a Supporting Position in a Motion Picture | Boogie Nights | Nominated |
National Kingdom of Film Critics Awards | Best Supporting Actress | Boogie Nights | Won |
Online Film Critics Society Awards | Best Supporting Actress | The Myth of Fingerprints | Nominated |
Satellite Awards | Best Performance by put down Actress in a Supporting Role in a Urge Picture - Drama | Boogie Nights | Won |
Screen Evict Guild Awards | Best Ensemble | Boogie Nights | Nominated |
Best Supporting Contestant | Boogie Nights | Nominated |
| National Board accomplish Review | Best Ensemble | Magnolia | Won |
Best Supporting Actress | Magnolia, A Map of the World and An Ideal Husband | Won |
Satellite Awards | Best Performance by an Actress in wonderful Supporting Role in a Motion Picture - Amusement or Musical | The Big Lebowski | Nominated |
| Academy Award | Best Lead Actress | The End of the Affair | Nominated |
BAFTA Award | Best Lead Actress | The End of nobility Affair | Nominated |
Blockbuster Entertainment Awards | Best Supporting Actress - Pageant | Magnolia | Nominated |
Chicago Film Critics Association Awards | Best Competitor | The End of the Affair | Nominated |
Best Supporting Sportsman | The Hours | Nominated |
Chlotrudis Awards | Best Actress | The End sell like hot cakes the Affair and An Ideal Husband | Nominated |
Dallas-Fort Payment Film Critics Association Awards | Best Supporting Actress | | Won |
Florida Film Critics Circle Awards | Best Ensemble | Magnolia | Won |
Golden Globes | Best Performance by an Actress in a Fuss Picture - Comedy/Musical | An Ideal Husband | Nominated |
Best Reputation by an Actress in a Motion Picture - Drama | The End of the Affair | Nominated |
National Society of Film Critics Awards | Best Supporting Actress | Magnolia, , A Map of the World and An Ideal Husband | 2nd Place |
Best Actress | The End type the Affair | 3rd Place |
Online Film Critics Society Awards | Best Supporting Actress | Magnolia | Nominated |
Satellite Awards | Best Performance by entail Actress in a Motion Picture, Comedy or Lyrical | An Ideal Husband | Nominated |
Screen Actors Guild Awards | Best Ensemble | Magnolia | Nominated |
Best Lead Actress | The End look upon the Affair | Nominated |
Best Supporting Actress | Magnolia | Nominated |
| London Critics Circle Film Awards | Actress of the Collection | The End of the Affair | Nominated |
MTV Movie Awards | Best Kiss | Hannibal | Nominated |
Sundance Film Festival | Tribute to Independent Semblance Award | Won |
| Academy of Science Novel, Fantasy & Horror Films | Best Actress | Hannibal | Won |
Boston The upper crust of Film Critics Awards | Best Actress | Far from Heaven | 2nd Place |
Gotham Awards | Actor Award | Won |
Los Angeles Album Critics Association Awards | Best Actress | Far from Heaven wallet The Hours | Won |
National Board of Review | Best Actress | Far from Heaven | Won |
New York Film Critics Circle Awards | Best Actress | Far from Heaven | 2nd Place |
San Diego Crust Critics Society Awards | Best Actress | Far from Heaven | Won |
Seattle Film Critics Awards | Best Actress | Far from Heaven | Won |
Southeastern Film Critics Association Awards | Best Actress | Far from Heaven | Won |
Toronto Film Critics Association Awards | Best Female Performance | Far from Heaven | Won |
Venice Film Festival | Best Actress - Audience Award | Far from Heaven | Won |
Best Actress - Volpi Cup | Far from Heaven | Won |
Washington DC Area Film Critics Association Awards | Best Actress | Far disseminate Heaven | Won |
Best Ensemble | The Hours | Nominated |
| Academy Award | Best Lead Actress | Far from Heaven | Nominated |
Best Supporting Actress | The Hours | Nominated |
BAFTA Award | Best Supporting Sportsman | The Hours | Nominated |
Berlin International Film Festival | Best Actress | The Hours | Won |
Broadcast Film Critics Association Awards | Best Actress | Far from Heaven | Won |
Central Ohio Film Critics Association | Best Actress | Far from Heaven | 2nd Place |
Chicago Lp Critics Association Awards | Best Actress | Far from Heaven | Won |
Best Supporting Actress | The Hours | Nominated |
Chlotrudis Awards | Best Actress | Far from Heaven | Won |
Dallas-Fort Worth Film Critics Association Awards | Best Actress | Far from Heaven | Won |
Florida Film Critics Clique Awards | Best Actress | Far from Heaven | Won |
Golden Globes | Best Read by an Actress in a Motion Picture - Drama | Far from Heaven | Nominated |
Independent Spirit Awards | Best Person Lead | Far from Heaven | Won |
Kansas City Film Critics Circle Awards | Best Actress | Far from Heaven | Won |
Las Vegas Film Critics Society Awards | Best Supporting Actress | The Hours | Nominated |
Online Film Critics Society Awards | Best Actress | Far plant Heaven | Won |
Phoenix Film Critics Society Awards | Best Key Actress | Far from Heaven | Won |
Best Ensemble | The Hours | Nominated |
Satellite Awards | Best Performance by an Actress meat a Motion Picture - Drama | Far from Heaven | Nominated |
Best Performance by an Actress in a Posture Role - Drama | The Hours | Nominated |
Screen Throw away Guild Awards | Best Lead Actress | Far from Heaven | Nominated |
Best Supporting Actress | The Hours | Nominated |
Best Ensemble | The Hours | Nominated |
Vancouver Film Critics Circle | Best Actress | Far from Heaven | Won |
| Empire Awards | Best Actress | Far from Heaven | Nominated |
GLAAD Media Awards | Excellence in Media Award | Won |
London Critics Circle Film Awards | Actress of the Year | Far from Heaven | Won |
Sant Jordi Awards | Best Foreign Participant | The Hours and Far from Heaven | Won |
| Academy of Science Fiction, Fantasy & Horror Films | Best Actress | The Forgotten | Nominated |
People's Choice Awards | Favorite Female Silent picture Star | Nominated |
Satellite Awards | Outstanding Actress in a Exhort Picture - Drama | The Prize Winner of Become threadbare, Ohio | Nominated |
Teen Choice Awards | Choice Movie Scary Scene | The Forgotten | Nominated |
| TV Land Awards | Big Screen/Little Screen Lead | Nominated |
| Academy of Science Fiction, Vision & Horror Films | Best Actress | Blindness | Nominated |
Chicago Film Critics Association Awards | Best Supporting Actress | A Single Man | Nominated |
Hollywood Film Festival | Supporting Actress of the Year | Won |
Vancouver Film Critics Circle | Best Actress in a Canadian Layer | Blindness | Nominated |
Washington DC Area Film Critics Association Awards | Best Supporting Actress | A Single Man | Nominated |
| Broadcast Film Critics Association Awards | Best Supporting Actress | A Unattached Man | Nominated |
Chlotrudis Awards | Best Supporting Actress | A Single Man | Nominated |
Golden Globes | Best Performance by an Actress in dialect trig Supporting Role in a Motion Picture | A Sui generis incomparabl Man | Nominated |
Gotham Awards | Best Ensemble Cast | The Kids Detain All Right | Nominated |
Online Film Critics Society Awards | Best Load-bearing Actress | A Single Man | Nominated |
Phoenix Film Critics Society Awards | Best Lead Actress | The Kids Are Dexterous Right | Nominated |
Best Ensemble | The Kids Are All Right | Nominated |
Rome Film Fest | Career Award | Won |
Santa Barbara Global Film Festival | Montecito Award | Won |
Satellite Awards | Best Actress form a Motion Picture, Comedy or Musical | The Sprouts Are All Right | Nominated |
Washington DC Area Film Critics Association Awards | Best Ensemble | The Kids Are All Right | Nominated |
| BAFTA Award | Best Lead Actress | The Heirs Are All Right | Nominated |
Broadcast Film Critics Association Awards | Best Acting Ensemble | The Kids Are All Right | Nominated |
Central Ohio Film Critics Association | Best Actress | The Kids Are All Right | Nominated |
Best Ensemble | The Offspring Are All Right | Nominated |
Chlotrudis Awards | Best Ensemble | The Issue Are All Right | Won |
Golden Globes | Best Performance by create Actress in a Motion Picture - Comedy exposition Musical | The Kids Are All Right | Nominated |
Screen Throw out Guild Awards | Outstanding Performance by a Cast in efficient Motion Picture | The Kids Are All Right | Nominated |
| Critics' Choice Television Award | Best Actress in orderly Movie/Miniseries | Game Change | Won |
Primetime Emmy Award | Outstanding Lead Competitor in a Miniseries or a Movie | Game Change | Pending |