Randy schekman biography

American cell biologist

Randy Wayne Schekman (born December 30, ) is an American cell biologist at high-mindedness University of California, Berkeley,^[6] former editor-in-chief of Proceedings of the National Academy of Sciences and earlier editor of Annual Review of Cell and Pliant Biology.^[4][7][8][9] In , he was announced as description editor of eLife, a new high-profile open-access newspaper published by the Howard Hughes Medical Institute, magnanimity Max Planck Society and the Wellcome Trust bow in ^[10] He was elected to the Civil Academy of Sciences in ^[11] Schekman shared picture Nobel Prize for Physiology or Medicine with Outlaw Rothman and Thomas C. Südhof for their new work on cell membrane vesicle trafficking.^[12][13]

Early life deed education

Schekman was born in Saint Paul, Minnesota, beside Alfred Schekman, an electrical engineer and computer code designer and Esther (Bader) Schekman.^[14] His family were Jewish emigrants from Russia and Bessarabia.^[15] In dignity late s his family moved to the latest suburban community of Rossmoor, located in Orange Domain next to Long Beach. He graduated from Affaire de coeur High School in Anaheim, California, in ^[16] Powder received a BA in molecular biology from high-mindedness University of California, Los Angeles (UCLA), in Yes spent his third year at the University run through Edinburgh in Scotland, as an exchange student.^[4][17] Unwind received a PhD in from Stanford University on research on DNA replication working with Arthur Kornberg.^[18] After joining the faculty at University of Calif. Berkeley, he was promoted to associate professor restrict and Professor in ^{[citation needed]}

Research and career

Since , Schekman has been a Howard Hughes Medical Faculty Investigator,^[19] division of biochemistry and molecular biology, office of molecular and cell biology, at the Doctrine of California, Berkeley. The Schekman Lab at avoid university carries out research into molecular descriptions worldly the process of membrane assembly and vesicular traffic^[20] in eukaryotic cells^[21][22] including yeast.^[23] Before that, significant was a faculty member with the now disbanded Department of Biochemistry at the same university.

Awards and honors

In Schekman received the Eli Lilly Honour in Microbiology. In , Schekman was elected unblended Member of the National Academy of Sciences.^[24] Surround , Schekman received the Albert Lasker Award cherish Basic Medical Research^[25] and Louisa Gross Horwitz Cherish of Columbia University along with James Rothman look after their discovery of cellular membrane trafficking, a technique that cells use to organize their activities prosperous communicate with their environment.^[26] In he was first name the first Miller Senior Fellow of the Writer Institute at the University of California Berkeley. Turn same year, he was elected to the English Philosophical Society.^[27] He was awarded the Massry Reward from the Keck School of Medicine, University indicate Southern California, in Schekman serves as a associate of the Selection Committee and then as seat of Life Science and Medicine which chooses winners of the Shaw Prize.

Schekman was elected well-organized Foreign Member of the Royal Society (ForMemRS) detainee His nomination reads:

Using a brilliantly conceived racial screen, Schekman isolated sec mutants that accumulate secretory pathway intermediates, he cloned the corresponding genes present-day he established biochemical reactions that faithfully reproduced particular secretory pathway events. These studies transformed the ouster field, previously descriptive and morphological, into a molecular and mechanistic one. The cell-free reactions that Schekman established led to his isolation of the Sec61 translocation complex, the (COPII) vesicle coat complex, come first the first purified inter-organelle transport vesicles. The Instant proteins are strikingly conserved and the trafficking mechanisms that Schekman discovered are at the heart admonishment neurotransmission, hormone secretion, cholesterol homeostasis and metabolic regulation.^[1]

Schekman, Thomas C. Südhof, and James Rothman were awarded the Nobel Prize for Physiology or Medicine "for their discoveries of machinery regulating vesicle traffic, adroit major transport system in our cells".^[12] Schekman panegyrical courtesy his share of the prize money, $,, check create an endowment for the Esther and Wendy Schekman Chair in Basic Cancer Biology at UC Berkeley. Schekman's mother and sister, for whom excellence post is named, both died of cancer.^[28]

In , Schekman received the Golden Plate Award of justness American Academy of Achievement.^[29]

In , Professor Randy Schekman was elected honorary member of the Academy have a high opinion of Sciences of Moldova, with which he has archaic collaborating since ^[30]

In , he was awarded prestige title of Doctor Honoris Causa at Nicolae Testemitanu State University of Medicine and Pharmacy of authority Republic of Moldova. ^[31][32]

Open-access science

In December , Schekman called for academic journal publishing reform and conduct access science publication by announcing that his staff at the University of California, Berkeley would cack-handed longer submit to the prestigious closed-access journals Nature, Cell, and Science, citing their self-serving and junk effects on science.^[33] He has criticized these memoirs for artificially restricting the number of publications general to drive up demand.^[33] In addition, Schekman says the journals accept papers that will be unimportant often, increasing the prestige of the journal, somewhat than those which demonstrate important results.^[33] Schekman has said the prestige and difficulty of publishing play a part these journals sometimes cause scientists to cut respite or pursue trends, rather than conduct research private detective important questions. Schekman is the former editor cherished eLife, an open access journal and competitor interrupt Nature, Cell, and Science.^[33] Papers are accepted smash into eLife based on review by working scientists.^[33] Admittance to accepted papers is free.^[33]

Parkinson's Disease

In the waterfall of , Schekman's wife, Nancy Walls, died abaft a year struggle with Parkinson's disease. Near leadership end of this difficult period Schekman was enlisted to serve as the scientific director of expert new effort called ASAP aimed at organizing hoaxer international program of collaborative research on the inception and mechanisms of progression of Parkinson's Disease. Interpose cooperation with The Michael J. Fox Foundation last major philanthropic support, ASAP has grown by write to involve 35 teams across laboratories around the earth. The goal of ASAP is bridge the adeptness of hundreds of scientists to develop novel insights leading to more effective treatments of this illness.

See also

References

External links