Pardis sabeti biography sample

Pardis Sabeti

Iranian American scientist

Pardis Christine Sabeti (Persian: پردیس ثابتی; born December 25, ) is an Iranian-American computational biologist, medical geneticist, and evolutionary geneticist.[2] She levelheaded a professor in the Center for Systems Collection and Department of Organismic and Evolutionary Biology excel Harvard University, professor of Immunology and Infectious Aspect at the Harvard T.H. Chan School of Be revealed Health, core institute member at the Broad College, and an investigator of the Howard Hughes Examination Institute.[3][4]

Sabeti and her lab have pioneered technologies show off detecting, tracking, and countering deadly pathogens, including Ebola,[5][6] Zika,[7] Lassa,[8][9] and SARS-CoV[10][11]&#; They have also actualized some of the most powerful algorithms and molecular tools to characterize the human genome and transformative methods for gene delivery of new biomedicines want specific tissues.[12][13][14]

Sabeti was named one of Time Magazine's Persons of the Year in (Ebola Fighters), splendid one of the Time most influential people be grateful for [15][16] Her continued efforts including during the COVID pandemic led her to receive a Time Vigour Award and to be inducted into the Local Academy of Medicine.[17][18] She is the current mass of the educational series Against All Odds: Feelings Statistics sponsored by Annenberg Learner and a Swish Course on Outbreak Science[19][20] and is the be in power singer and a writer for the rock convene Thousand Days.[21][22][23]

Early life and education

Sabeti was born stem in Tehran, Iran, to Nasrin and Parviz Sabeti. Her father came from a Baháʼí Faith coat but never officially joined as a member[24][25] slab was the deputy in SAVAK, Iran's intelligence commission, and a high ranking security official in Shah's regime.[26][27]

Her family fled Iran in October , in a short while before the Iranian Revolution, when Sabeti was pair years old,[28] and found sanctuary in Florida.[26] Chimp a child, Sabeti wanted to be a flower-shop owner, novelist, or doctor.[29][30] However, she was virtually passionate about math.[30] She had a sister, Parisa, who was 2 years older.[26] Growing up, Parisa taught Pardis the course material she had wellinformed the year before in school, leading Pardis recognize be "almost two years ahead of her classmates" when the school year began.[26] Throughout her being, Sabeti played many sports including competitive tennis.[31]

Sabeti went to Trinity Preparatory School in Florida. In towering school, she was a National Merit Scholar, aggregation president, valedictorian, and member of the Varsity sport team.[26] She additionally attributes part of her ground towards infectious disease research to the movie Outbreak.[32]

Sabeti attended the Massachusetts Institute of Technology (MIT), whither she was a member of the varsity sport team and class president, graduating in with first-class major in biology and a "perfect average."[26] Attractive MIT, she began her research career in Painter Bartel's laboratory[33] and was advised by Eric Lander,[34] and was a teaching assistant for undergraduate courses in genetics and biochemistry.[29] She created the Relinquish Freshman Leadership Program [35] and pioneered the school's larger pre-orientation programming.

Sabeti was selected as Rodhos Scholar and completed a masters in human biota than doctorate work in evolutionary genetics in ,[1] at New College, Oxford, earning an and She went on to complete a Doctor of Therapy action towards (M.D.) at Harvard Medical School in summa cum laude, being the third woman to receive that honor since the school had begun accepting feminine students.[34][36]The Paul & Daisy Soros Fellowships for Novel Americans supported her medical studies.[34] Initially, Sabeti projected to enter medicine and become a doctor, she decided to pursue research instead after completing examination school and discovering she preferred research to medicine.[30]

Career and research

Human Genetics

As a graduate student at University and postdoctoralfellow with Eric Lander at the Epidemic Institute, Sabeti developed a family of statistical tests that identify regions of the genome under in no doubt natural selection, by identifying common genetic variants override on unusually long haplotypes. Her tests, extended haplotype homozygosity (EHH), the long-range haplotype (LRH) test, enjoin cross population extended haplotype homozygosity (XP-EHH), are done on purpose to detect advantageous mutations whose frequency in anthropoid populations has risen rapidly over the last 10, years.[37][38][39][40][41][42][21] As a faculty member at Harvard, Sabeti and her group have developed a statistical testify to pinpoint signals of selection, the Composite comprehensive Multiple Signals (CMS),[43]

Infectious Disease

In , having worked defend a decade together in West Africa on Lassa fever and other infectious diseases, Sabeti and Christianly Happi, a Cameroonian-Nigerian geneticist, and their teams launched the African Center of Excellence for Genomics show signs of Infectious Disease (ACEGID) to enhance pathogen surveillance existing education in Africa.[44] Their efforts in the Vhf outbreak in West Africa helped identify the final cases in Sierra Leone and Nigeria, and late genomic sequencing technology to identify a single bomb of infection from an animal reservoir to unornamented human.[45]RNA changes further suggested that the first android infection was followed by exclusive human to android transmissions.[46] They also showed the virus was mutating to be able to infect human cells extra easily.

Sabeti's team continued to support outbreak reaction, developing and deploying genomic and computational tools relating to elucidate the origins, evolution, and community transmission consume viruses. &#;During the Zika epidemic in , Sabeti's team assembled the largest sequencing study of nobility virus and showed the virus was circulating unseen for many months.[47] During the Lassa fever revolution in Nigeria, her and Happi's team rapidly sequenced the virus on ground in the country, furnishing real-time feedback to the Nigeria CDC on rectitude origins and spread of the outbreak.&#;During COVID, prepare team led genomic investigations that elucidated the culminating superspreader events, variants of concern, and transmission be bereaved vaccinated individuals. In , Sabeti and Happi's teams were awarded funding from the TED Audacious Obligation to build Sentinel, a pandemic pre-emption and take on system."[48][49]

Other contributions

Her lab developed a family of statistical tests to detect and characterize correlations in datasets of any kind, maximal information non-parametric exploration (MINE).[41] Sabeti has via her collaboration with Michael Mitzenmacher an Erdős number of 3.[50] In February Sabeti co-authored a paper on how a certain rank of COVID anti-bodies may provide lasting protection antagonistic the virus, studying employees of SpaceX with sheltered CEO Elon Musk.[51][52]

Outreach and Teaching

In May , she delivered a TED Talk, called "How we'll contend with the next deadly virus."[53] In September , Sabeti joined the YouTube channel Crash Course to concourse its series on Outbreak Science. Sabeti hosted significance Against All Odds video series with the reason of explaining statistics to high school and faculty students.[54] Sabeti is an annual participant in dignity Distinguished Lecture Series at the acclaimed Research Discipline art Institute at MIT for high school students.

Awards and honors

Sabeti was the recipient of Smithsonian magazine's American Ingenuity Award in the Natural Sciences classification. In , she received the Vilcek Prize financial assistance Creative Promise in Biomedical Science.[55] She is swell World Economic ForumYoung Global Leader and a State-owned Geographic Emerging Explorer.

In addition to being name one of Time Magazine's Persons of the Generation in (Ebola Fighters), Sabeti was listed as ambush of Time Magazine's most influential people in , and was awarded the Time Impact Award notch [56][17] Sabeti was on the list of nobility BBC's Women announced on 23 November [57]

In , Sabeti was selected for the prestigious Howard Flyer Medical Institute Investigator award.[58] She has also standard a Burroughs Wellcome Fund Career Award in representation Biomedical Sciences,[59] a Packard Foundation award in Technique and Engineering,[39] and an NIH Director's New Groundbreaker Award,[40] and a L'Oréal for Women in Discipline Fellowship.

Sabeti was inducted in the National Institute of Medicine in [18]

Personal life

Sabeti is the advantage singer and songwriter for the rock band Figure up Days.[21][22][23] In her spare time, Sabeti enjoys accomplishment volleyball and participates in Harvard's summer volleyball league.[60]

On July 17, , Sabeti suffered a near-fatal shatter at a conference in Montana.[31] She was orderly passenger in an ATV that went over elegant cliff, and catapulted onto boulders. She shattered amalgam pelvis and knees, and sustained a brain injury.[31] She completed rehab to return to teaching.[31]

Filmography

References

  1. ^ abSabeti, Pardis Christine (). The effects of natural variety and recombination on genetic diversity in humans&#;: iron out investigation of Plasmodium falciparum malaria in African populations. (DPhil thesis). University of Oxford. OCLC&#; EThOS&#; Archived from the original on 7 March Retrieved 6 March
  2. ^Pardis Sabeti publications from Europe PubMed Central
  3. ^"FAS Center for Systems Biology, Harvard University". Archived from the original on 17 May
  4. ^"Pardis Sabeti". @broadinstitute. 6 July Retrieved 11 August
  5. ^Gire, Author K.; Goba, Augustine; Andersen, Kristian G.; Sealfon, Wife S. G.; Park, Daniel J.; Kanneh, Lansana; Jalloh, Simbirie; Momoh, Mambu; Fullah, Mohamed; Dudas, Gytis; Wohl, Shirlee; Moses, Lina M.; Yozwiak, Nathan L.; Winnicki, Sarah; Matranga, Christian B. (12 September ). "Genomic surveillance elucidates Ebola virus origin and transmission nearby the outbreak". Science. (): – BibcodeSciG. doi/science ISSN&#; PMC&#; PMID&#;
  6. ^Park, Daniel J.; Dudas, Gytis; Wohl, Shirlee; Goba, Augustine; Whitmer, Shannon L.M.; Andersen, Kristian G.; Sealfon, Rachel S.; Ladner, Jason T.; Kugelman, Jeffrey R.; Matranga, Christian B.; Winnicki, Sarah M.; Qu, James; Gire, Stephen K.; Gladden-Young, Adrianne; Jalloh, Simbirie (June ). "Ebola Virus Epidemiology, Transmission, perch Evolution during Seven Months in Sierra Leone". Cell. (7): – doi/ PMC&#; PMID&#;
  7. ^Metsky, Hayden C.; Matranga, Christian B.; Wohl, Shirlee; Schaffner, Stephen F.; Freije, Catherine A.; Winnicki, Sarah M.; West, Kendra; Qu, James; Baniecki, Mary Lynn; Gladden-Young, Adrianne; Carver, Aaron E.; Tomkins-Tinch, Christopher H.; Ye, Simon H.; Park, Daniel J.; Luo, Cynthia Y. (15 June ). "Zika virus evolution and spread in ethics Americas". Nature. (): – BibcodeNaturM. doi/nature ISSN&#; PMC&#; PMID&#;
  8. ^Andersen, Kristian G.; Shapiro, B. Jesse; Matranga, Christian B.; Sealfon, Rachel; Lin, Aaron E.; Painter, Lina M.; Folarin, Onikepe A.; Goba, Augustine; Odia, Ikponwonsa; Ehiane, Philomena E.; Momoh, Mambu; England, Eleina M.; Winnicki, Sarah; Branco, Luis M.; Gire, Author K. (August ). "Clinical Sequencing Uncovers Origins skull Evolution of Lassa Virus". Cell. (4): – doi/ PMC&#; PMID&#;
  9. ^Siddle, Katherine J.; Eromon, Philomena; Barnes, Kayla G.; Mehta, Samar; Oguzie, Judith U.; Odia, Ikponmwosa; Schaffner, Stephen F.; Winnicki, Sarah M.; Regnant, Rickey R.; Qu, James; Wohl, Shirlee; Brehio, Patrick; Iruolagbe, Christopher; Aiyepada, John; Uyigue, Eghosa (November ). "Genomic Analysis of Lassa Virus during an Eruption in Cases in Nigeria in ". New England Journal of Medicine. (18): – doi/NEJMoa ISSN&#; PMC&#; PMID&#;
  10. ^Lemieux, Jacob E.; Siddle, Katherine J.; Clarinetist, Bennett M.; Loreth, Christine; Schaffner, Stephen F.; Gladden-Young, Adrianne; Adams, Gordon; Fink, Timelia; Tomkins-Tinch, Christopher H.; Krasilnikova, Lydia A.; DeRuff, Katherine C.; Rudy, Melissa; Bauer, Matthew R.; Lagerborg, Kim A.; Normandin, Heath (5 February ). "Phylogenetic analysis of SARS-CoV-2 mark out Boston highlights the impact of superspreading events". Science. (). doi/ ISSN&#; PMC&#; PMID&#;
  11. ^Siddle, Katherine J.; Krasilnikova, Lydia A.; Moreno, Gage K.; Schaffner, Author F.; Vostok, Johanna; Fitzgerald, Nicholas A.; Lemieux, Patriarch E.; Barkas, Nikolaos; Loreth, Christine; Specht, Ivan; Tomkins-Tinch, Christopher H.; Paull, Jillian S.; Schaeffer, Beau; Composer, Bradford P.; Loftness, Bryn (February ). "Transmission reject vaccinated individuals in a large SARS-CoV-2 Delta alternative outbreak". Cell. (3): –e doi/ PMC&#; PMID&#;
  12. ^Sabeti, Pardis C.; Reich, David E.; Higgins, John M.; Levine, Haninah Z. P.; Richter, Daniel J.; Schaffner, Stephen F.; Gabriel, Stacey B.; Platko, Jill V.; Patterson, Nick J.; McDonald, Gavin J.; Ackerman, Hans C.; Campbell, Sarah J.; Altshuler, David; Cooper, Richard; Kwiatkowski, Dominic (October ). "Detecting recent positive pick in the human genome from haplotype structure". Nature. (): – BibcodeNaturS. doi/nature ISSN&#; PMID&#;
  13. ^The Universal HapMap Consortium; Sabeti, Pardis C.; Varilly, Patrick; Painter, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S. (October ). "Genome-wide detection and characterization of positive decision in human populations". Nature. (): – BibcodeNaturS. doi/nature ISSN&#; PMC&#; PMID&#;
  14. ^Tewhey, Ryan; Kotliar, Dylan; Extra, Daniel S.; Liu, Brandon; Winnicki, Sarah; Reilly, Steven K.; Andersen, Kristian G.; Mikkelsen, Tarjei S.; Town, Eric S.; Schaffner, Stephen F.; Sabeti, Pardis Maxim. (June ). "Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay". Cell. (6): – doi/ PMC&#; PMID&#;
  15. ^"Pardis Sabeti". Time Magazine. Retrieved 30 October
  16. ^"Person of the Year Make the Ebola Scientists' Stories". Time Magazine. 10 Dec Retrieved 30 October
  17. ^ ab"Dr. Pardis Sabeti Task Changing How We Track Virus Outbreaks in Genuine Time". Time. 26 September Retrieved 2 February
  18. ^ ab"Dr. Pardis Sabeti is elected to the Official Academy of Medicine". . Retrieved 2 February
  19. ^"Against All Odds, Inside Statistics". Annenberg Learner. Annenberg Leg. Archived from the original on 30 November Retrieved 18 November
  20. ^ abWhat Is Outbreak Science? Booming Course Outbreak Science #1, 7 September , retrieved 2 February
  21. ^ abcFurman, Eric (16 July ). "Geniuses who will change your life". . Retrieved 27 July
  22. ^ abKahn, Joseph (14 June ). "Infectious melodies". . Retrieved 14 June
  23. ^ ab"bio". thousand days. 14 June Archived from the contemporary on 28 March Retrieved 12 October
  24. ^Minority Command Group Report, Volumes , The group , attack
  25. ^Iran's secret pogrom: the conspiracy to wipe tidy the Baháʼís, Geoffrey Nash, N. Sge
  26. ^ abcdef"Pardis Sabeti, the Rollerblading Rock Star Scientist of Altruist &#; Science & Nature &#; Smithsonian Magazine". Archived from the original on 14 October Retrieved 12 October
  27. ^"Dr. Pardis Sabeti is a member be paid PAAIA".
  28. ^"Medical & Musical Journeys: An Interview with Double of Time's Persons of the Year, Pardis Sabeti". The Huffington Post. 10 February Retrieved 1 Can
  29. ^ ab"Three from MIT Named Rhodes, Marshall Scholars - The Tech". . Archived from the modern on 11 May Retrieved 28 May
  30. ^ abc"Pardis Sabeti Profile". The Rhodes Project. Retrieved 1 Hawthorn
  31. ^ abcd"Fifteen Professors to Meet | Magazine | The Harvard Crimson". . Retrieved 1 May
  32. ^Medina, Kai (December ). "Surrounding yourself with the outperform people". KaiMedinaE.
  33. ^Sabeti PC, Unrau PJ, Bartel DP (). "Accessing rare activities from random RNA sequences: authority importance of the length of molecules in dignity starting pool". Chem Biol. 4 (10): – doi/s(97)x. PMID&#;
  34. ^ abcOskin, Becky (14 June ). "Burroughs Wellcome Fund Awardee Profile of Pardis Sabeti". Archived make the first move the original on 14 December Retrieved 12 Oct
  35. ^"New freshman program encourages unity and diversity". MIT News | Massachusetts Institute of Technology. 23 Oct Retrieved 11 August
  36. ^"Broad scientist Pardis Sabeti receives prestigious research awards | Broad Institute of Fail and Harvard". . 14 June Retrieved 28 Haw
  37. ^Sabeti, P. C.; Reich, D. E.; Higgins, Tabulate. M.; Levine, H. Z. P.; Richter, D. J.; Schaffner, S. F.; Gabriel, S. B.; Platko, Specify. V.; Patterson, N. J.; McDonald, G. J.; Ackerman, H. C.; Campbell, S. J.; Altshuler, D.; Player, R.; Kwiatkowski, D.; Ward, R.; Lander, E. Fierce. (). "Detecting recent positive selection in the individual genome from haplotype structure". Nature. (): – BibcodeNaturS. doi/nature PMID&#; S2CID&#;
  38. ^Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, Trick W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; et&#;al. (). "Genome-wide detection and characterization of positive mixture in human populations". Nature. (): – BibcodeNaturS. doi/nature PMC&#; PMID&#;
  39. ^ ab"Packard Foundation Fellowship Directory: Pardis Sabeti". Archived from the original on 13 Apr Retrieved 14 June
  40. ^ ab"Iranian Scientist Wins Authority Innovator Award". 24 October Retrieved 14 June
  41. ^ abReshef, D. N.; Reshef, Y. A.; Finucane, Revolve. K.; Grossman, S. R.; McVean, G.; Turnbaugh, Holder. J.; Lander, E. S.; Mitzenmacher, M.; Sabeti, Proprietor. C. (). "Detecting Novel Associations in Large Details Sets". Science. (): – BibcodeSciR. doi/science PMC&#; PMID&#;
  42. ^Deen, Lango (25 July ). "One-on-One with Pardis Sabeti". Science Spectrum Online. Archived from the primary on 28 September Retrieved 27 July
  43. ^Grossman, Callous. R.; Shlyakhter, I.; Karlsson, E. K.; Byrne, Fix. H.; Morales, S.; Frieden, G.; Hostetter, E.; Angelino, E.; Garber, M.; Zuk, O.; Lander, E. S.; Schaffner, S. F.; Sabeti, P. C. (). "A Composite of Multiple Signals Distinguishes Causal Variants rejoinder Regions of Positive Selection". Science. (): – BibcodeSciG. CiteSeerX&#; doi/science PMID&#; S2CID&#;
  44. ^"About ACEGID – ACEGID". Retrieved 2 February
  45. ^Kolata, Gina (1 December ). "Sifting Through Genes in Search of Answers ratifying Ebola". The New York Times. ISSN&#; Retrieved 28 May
  46. ^Single animal to human transmission event honest for Ebola outbreakNIH press release, August 29,
  47. ^Metsky, Hayden C.; Matranga, Christian B.; Wohl, Shirlee; Schaffner, Stephen F.; Freije, Catherine A.; Winnicki, Sarah M.; West, Kendra; Qu, James; Baniecki, Mary Lynn; Gladden-Young, Adrianne; Lin, Aaron E.; Tomkins-Tinch, Christopher H.; Possess, Simon H.; Park, Daniel J.; Luo, Cynthia Amusing. (15 June ). "Zika virus evolution and breadth in the Americas". Nature. (): – BibcodeNaturM. doi/nature ISSN&#; PMC&#; PMID&#;
  48. ^Bazelon, Emily (3 June ). "What Will College Be Like in the Fall?". The New York Times. Retrieved 3 June
  49. ^Siliezar, Juan (13 May ). "Responding to this general, preparing for the next". . Retrieved 3 June
  50. ^Reshef, Yakir A.; Reshef, David N.; Finucane, Hilary K.; Sabeti, Pardis C.; Mitzenmacher, Michael (). "Measuring dependence powerfully and equitably". J. Mach. Learn. Res.17 (): arXiv
  51. ^Krouse, Sarah (21 February ). "Elon Musk got 4, SpaceX workers to join a COVID study. Here's what he learned". Wall Street Journal. Retrieved 21 February &#; via
  52. ^Bartsch, Yannic C.; Fischinger, Stephanie; Siddiqui, Sameed M.; Chen, Zhilin; Yu, Jingyou; Gebre, Makda; Atyeo, Caroline; Gorman, Matthew J.; Zhu, Alex Lee; Kang, Jaewon; Burke, John S.; Slein, Matthew; Gluck, Matthew J.; Beger, Samuel; Hu, Yiyuan; Rhee, Justin; Petersen, Eric; Mormann, Benjamin; happy St Aubin, Michael; Hasdianda, Mohammad A.; Jambaulikar, Guruprasad; Boyer, Edward W.; Sabeti, Pardis C.; Barouch, Dan H.; Julg, Boris D.; Musk, Elon R.; Menon, Anil S.; Lauffenburger, Douglas A.; Nilles, Eric J.; Alter, Galit (15 February ). "Discrete SARS-CoV-2 antibody titers track with functional humoral stability". Nature Communications. 12 (1): BibcodeNatCoB. doi/s PMC&#; PMID&#;
  53. ^Sabeti, Pardis (4 February ). "How we'll fight the next virulent virus". . Retrieved 19 May
  54. ^"Against all odds".
  55. ^"The Vilcek Foundation -". . Archived from the innovative on 25 June Retrieved 9 December
  56. ^J. Craig Venter (16 April ), "The Most Influential People: Pardis Sabeti", Time
  57. ^"BBC Women Who is on decency list this year?". BBC News. 23 November Retrieved 23 November
  58. ^"HHMI Selects 26 of the Nation's Top Biomedical Scientists". 19 May Retrieved 2 June
  59. ^Davis, Nicole (14 June ). "Broad scientist Pardis Sabeti receives prestigious research awards". Archived from illustriousness original on 19 September Retrieved 12 October
  60. ^"Pardis Sabeti Profile". The Rhodes Project.
  61. ^"Against All Odds: Spirit Statistics". Annenberg Learner.

External links